Mechanical Ventilation Exacerbates Poly (I:C) Induced Acute Lung Injury: Central Role for Caspase-11 and Gut-Lung Axis

Mechanical Ventilation Exacerbates Poly (I:C) Induced Acute Lung Injury: Central Role for Caspase-11 and Gut-Lung Axis

BackgroundThe mechanisms by which moderate tidal volume ventilation (MTV) exacerbates preexisting lung injury are unclear. We hypothesized that systemic endotoxemia via the gut-lung axis would lead to non-canonical and canonical inflammasome activation and pyroptosis in a two-hit model involving pol...

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Bibliographic Details
Main Authors: Shuqing Jin, Xibing Ding, Chenxuan Yang, Wenbo Li, Meihong Deng, Hong Liao, Xin Lv, Bruce R. Pitt, Timothy R. Billiar, Li-Ming Zhang, Quan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
acute lung injury
Poly(I:C)
mechanical ventilation
gut-lung axis
systemic endotoxemia
caspase-11
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.693874/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.693874/full

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