Large Scale Conversion of Trilobolide into the Payload of Mipsagargin: 8-<i>O</i>-(12-Aminododecanoyl)-8-<i>O</i>-Debutanoylthapsigargin

Large Scale Conversion of Trilobolide into the Payload of Mipsagargin: 8-<i>O</i>-(12-Aminododecanoyl)-8-<i>O</i>-Debutanoylthapsigargin

In spite of the impressing cytotoxicity of thapsigargin (<b>Tg</b>), this compound cannot be used as a chemotherapeutic drug because of general toxicity, causing unacceptable side effects. Instead, a prodrug targeted towards tumors, mipsagargin, was brought into clinical trials. What sub...

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Bibliographic Details
Main Authors: Tomáš Zimmermann, Pavel Drašar, Silvie Rimpelová, Søren Brøgger Christensen, Vladimir A. Khripach, Michal Jurášek
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biomolecules
Subjects:
chemical synthesis
extraction
mipsagargin
trilobolide isolation from fruits
optimization and scale-up
<i>Laser trilobum</i> cultivation
Online Access:https://www.mdpi.com/2218-273X/10/12/1640

Internet

https://www.mdpi.com/2218-273X/10/12/1640

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