Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis.

Heparan sulfate (HS) is an important regulator of the assembly and activity of various angiogenic signalling complexes. However, the significance of precisely defined HS structures in regulating cytokine-dependent angiogenic cellular functions and signalling through receptors regulating angiogenic r...

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Bibliographic Details
Main Authors: Claire L Cole, Steen U Hansen, Marek Baráth, Graham Rushton, John M Gardiner, Egle Avizienyte, Gordon C Jayson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2908126?pdf=render