Immunogenicity of adenovirus-vector vaccine targeting hepatitis B virus: non-clinical safety assessment in non-human primates

Immunogenicity of adenovirus-vector vaccine targeting hepatitis B virus: non-clinical safety assessment in non-human primates

Abstract Background A new promising therapeutic approach has emerged for patients chronically infected by the hepatitis B virus (HBV) with the development of a non-replicative adenovirus vector vaccine candidate (Ad-HBV). The vaccine encodes a fusion protein composed of a truncated HBV core protein,...

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Bibliographic Details
Main Authors: Xuefeng Zhang, Jing Wang, Jing Lu, Rongrong Li, Shuli Zhao
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Virology Journal
Subjects:
Adenovirus vector
Gene therapy
Hepatitis B virus
Immunogenicity
Safety assessment
Online Access:http://link.springer.com/article/10.1186/s12985-018-1026-3

Internet

http://link.springer.com/article/10.1186/s12985-018-1026-3

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