Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP

Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP

Maritoclax, an active constituent isolated from marine bacteria, has been known to induce Mcl-1 downregulation through proteasomal degradation. In this study, we investigated the sensitizing effect of maritoclax on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in...

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Bibliographic Details
Main Authors: Mi-Yeon Jeon, Kyoung-jin Min, Seon Min Woo, Seung Un Seo, Yung Hyun Choi, Sang Hyun Kim, Dong Eun Kim, Tae-Jin Lee, Shin Kim, Jong-Wook Park, Taeg Kyu Kwon
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
maritoclax
TRAIL
cFLIP
DR5
MicroRNA
ER stress
Online Access:https://www.mdpi.com/1420-3049/23/11/3030

Internet

https://www.mdpi.com/1420-3049/23/11/3030

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