First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity

First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity

<p>Abstract</p> <p>Background</p> <p>IMP321 is a recombinant soluble LAG-3Ig fusion protein that binds to MHC class II with high avidity and mediates APC and then antigen-experienced memory CD8<sup>+ </sup>T cell activation. We report clinical and biological...

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Bibliographic Details
Main Authors: Gligorov Joseph, Medioni Jacques, Bousetta Nabil, Cvitkovic Frédérique, Jarcau Rosana, Brain Etienne, Mefti Fawzia, Gutierrez Maya, Brignone Chrystelle, Grygar Caroline, Marcu Manon, Triebel Frédéric
Format: Article
Language:English
Published: BMC 2010-07-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/8/1/71

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http://www.translational-medicine.com/content/8/1/71

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