A palindromic CpG-containing phosphodiester oligodeoxynucleotide as a mucosal adjuvant stimulates plasmacytoid dendritic cell-mediated T(H)1 immunity.

A palindromic CpG-containing phosphodiester oligodeoxynucleotide as a mucosal adjuvant stimulates plasmacytoid dendritic cell-mediated T(H)1 immunity.

BACKGROUND: CpG oligodeoxynucleotides (ODNs), resembling bacterial DNA, are currently tested in clinical trials as vaccine adjuvants. They have the nuclease-resistant phosphorothioate bond; the immune responses elicited differ according to the CpG ODN sequence and vaccination method. To develop a Cp...

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Bibliographic Details
Main Authors: Jun-ichi Maeyama, Hisakazu Takatsuka, Fumiko Suzuki, Ayumi Kubota, Satomi Horiguchi, Takako Komiya, Ichiroh Shimada, Eri Murata, Youko Osawa, Harukazu Kitagawa, Takasumi Matsuki, Masanori Isaka, Saburo Yamamoto, Sumiko Iho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3933336?pdf=render

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http://europepmc.org/articles/PMC3933336?pdf=render

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