Genetically Modified Mouse Mesenchymal Stem Cells Expressing Non-Structural Proteins of Hepatitis C Virus Induce Effective Immune Response

Genetically Modified Mouse Mesenchymal Stem Cells Expressing Non-Structural Proteins of Hepatitis C Virus Induce Effective Immune Response

Hepatitis C virus (HCV) is one of the major causes of chronic liver disease and leads to cirrhosis and hepatocarcinoma. Despite extensive research, there is still no vaccine against HCV. In order to induce an immune response in DBA/2J mice against HCV, we obtained modified mouse mesenchymal stem cel...

Full description

Bibliographic Details
Main Authors:	Olga V. Masalova, Ekaterina I. Lesnova, Regina R. Klimova, Ekaterina D. Momotyuk, Vyacheslav V. Kozlov, Alla M. Ivanova, Olga V. Payushina, Nina N. Butorina, Natalia F. Zakirova, Alexander N. Narovlyansky, Alexander V. Pronin, Alexander V. Ivanov, Alla A. Kushch
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Vaccines
Subjects:	hepatitis c virus (hcv) mesenchymal stem cells (msc) modified msc dna immunization nonstructural hcv proteins immune response hcv vaccine myeloid derived suppressor cells (mdscs)
Online Access:	https://www.mdpi.com/2076-393X/8/1/62

Similar Items

Mesenchymal Stem Cells Can Both Enhance and Inhibit the Cellular Response to DNA Immunization by Genes of Nonstructural Proteins of the Hepatitis C Virus
by: Olga V. Masalova, et al.
Published: (2021-07-01)

Difluoromethylornithine (DFMO), an Inhibitor of Polyamine Biosynthesis, and Antioxidant <i>N</i>-Acetylcysteine Potentiate Immune Response in Mice to the Recombinant Hepatitis C Virus NS5B Protein
by: Ekaterina I. Lesnova, et al.
Published: (2021-06-01)

Spontaneous HCV clearance: an association with gender, age, viral genotypes, infection transmission routes, and markers of HBV and HIV
by: Sergey Valer'evich Fedorchenko, et al.
Published: (2010-03-01)

HCV-Associated Exosomes Upregulate RUNXOR and RUNX1 Expressions to Promote MDSC Expansion and Suppressive Functions through STAT3–miR124 Axis
by: Bal Krishna Chand Thakuri, et al.
Published: (2020-12-01)

Dendritic cells in the pathogenesis of viral hepatitis C
by: Elena Removna Chernykh, et al.
Published: (2019-07-01)

Hepatitis C Virus Improves Human Tregs Suppressive Function and Promotes Their Recruitment to the Liver
by: Laurissa Ouaguia, et al.
Published: (2019-10-01)

An overview of HCV molecular biology, replication and immune responses
by: Nawaz Zafar, et al.
Published: (2011-04-01)

Peripheral B cells as reservoirs for persistent HCV infection
by: Masahiko eIto, et al.
Published: (2011-08-01)

Lymphocyte Landscape after Chronic <i>Hepatitis C Virus</i> (HCV) Cure: The New Normal
by: Alip Ghosh, et al.
Published: (2020-10-01)

Hepatitis C virus quantification in serum and saliva of HCV-infected patients
by: Gisele Barreto Lopes Menezes, et al.
Published: (2012-08-01)

Feasibility of anti-HCV reflex HCV Ag screening strategy in an HCV endemic community
by: Wei-Ming Chen, et al.
Published: (2021-05-01)

Characterization of Host Protein Interactions with HCV RNA : Implications in Viral Translation, Replication and Design of Antivirals
by: Bhat, Prasanna
Published: (2018)

Hepatitis C virus infection in patients and family members attending two primary care clinics in Puebla, Mexico
by: Aurelio López-Colombo, et al.
Published: (2014-11-01)

Hepatitis C virus infection in a Brazilian population with sickle-cell anemia
by: M.C.M.R. Torres, et al.
Published: (2003-03-01)

Hepatitis C, Innate Immunity and Alcohol: Friends or Foes?
by: Natalia A. Osna, et al.
Published: (2015-02-01)

The prevalence of the hepatitis C virus among the conditionally healthy population of the Russian Federation
by: N. V. Soboleva, et al.
Published: (2017-06-01)

Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis and viral infection
by: YASUO eARIUMI
Published: (2014-12-01)

Distribution of HCV genotypes among different exposure categories in Brazil
by: Oliveira M.L.A., et al.
Published: (1999-01-01)

Diagnostic accuracy of a new commercially available HCV-antigen test
by: Marta Monari, et al.
Published: (2010-03-01)

Change in hepatitis C virus positivity among needle-stick injury source patients: a 10-year experience in a Japanese tertiary hospital
by: Kazuya Okushin, et al.
Published: (2021-04-01)

FEATURES OF CIRCULATION OF HEPATITIS C VIRUS IN KHABAROVSK REGION
by: N. V. Soboleva, et al.
Published: (2017-06-01)

Case of the HCV-associated immune thrombocytopenia in patient with chronic hepatitis C
by: Yu. Yu. Ryabokon
Published: (2012-04-01)

Recombinant in vitro assembled hepatitis C virus core particles induce strong specific immunity enhanced by formulation with an oil-based adjuvant
by: NELSON ACOSTA-RIVERO, et al.
Published: (2009-01-01)

Detection and distribution of genotypes of Hepatitis C in a tertiary care hospital
by: Upasana Bhumbla, et al.
Published: (2020-01-01)

Comparative studies in detection of anti-HCV antibodies using Abbott IMx HCV, Serodia-HCV and DETECT-HCVTM
by: Nisarat Apichartpiyakul, et al.
Published: (2010-01-01)

Most common HCV genotypes in patients from north-eastern Croatia
by: Magdalena Perić, et al.
Published: (2014-05-01)

Prevalence and Genotypic Distribution of Hepatitis C Virus in Peshawar KPK, Pakistan
by: Tanweer Kumar, et al.
Published: (2017-01-01)

Hepatitis C virus strategies to evade the specific-T cell response: a possible mission favoring its persistence
by: Jorge Fabián Quarleri, Ph.D., et al.
Published: (2016-01-01)

Sieroprevalenza di infezione da HBV e HCV tra pazienti in dialisi
by: Rosa Anna Leone, et al.
Published: (2003-12-01)

The Distribution of Hepatitis C Virus (HCV) Genotypes in 59 HCV Infected Patients: A Multicenter Study
by: Emine SÖNMEZ, et al.
Published: (1996-06-01)

The distribution of hepatitis C virus genotypes in patients with hepatocellular carcinoma
by: Ayfer Bakır, et al.
Published: (2019-10-01)

Consequences of inaccurate hepatitis C virus genotyping on the costs of prescription of direct antiviral agents in an Italian district
by: Polilli E, et al.
Published: (2016-09-01)

HCV eradication with IFN-based therapy does not completely restore gene expression in PBMCs from HIV/HCV-coinfected patients
by: Óscar Brochado, et al.
Published: (2021-03-01)

Prevalence and genetic diversity of HCV among HIV-1 infected individuals living in Ahvaz, Iran
by: Ali Teimoori, et al.
Published: (2019-05-01)

Effect of combined siRNA of HCV E2 gene and HCV receptors against HCV
by: Ashfaq Usman Alli A, et al.
Published: (2011-06-01)

HCV core antigen is an alternative marker to HCV RNA for evaluating active HCV infection: implications for improved diagnostic option in an era of affordable DAAs
by: Rujipat Wasitthankasem, et al.
Published: (2017-11-01)

Mechanistic Insights into Translation and Replication of Hepatitis C Virus RNA : Exploring Direct-Acting Antivirals
by: Kumar, Anuj
Published: (2018)

Study of cell host factors involved in Hepatitis C virus tropism
by: Da Costa, Daniel
Published: (2012)

Low intrafamilial transmission of hepatitis C virus in Central Brazil
by: R. M. B. Martins, et al.
Published: (1994-12-01)

Enhancement of humoral immunity in mice by coupling pUCpGs10 and aluminium to the HCV recombinant immunogen
by: Zhan Na, et al.
Published: (2011-11-01)

Cannot write session to /tmp/vufind_sessions/sess_akbh228r0tjc902u4sbrq577t4