Genetically Modified Mouse Mesenchymal Stem Cells Expressing Non-Structural Proteins of Hepatitis C Virus Induce Effective Immune Response

Genetically Modified Mouse Mesenchymal Stem Cells Expressing Non-Structural Proteins of Hepatitis C Virus Induce Effective Immune Response

Hepatitis C virus (HCV) is one of the major causes of chronic liver disease and leads to cirrhosis and hepatocarcinoma. Despite extensive research, there is still no vaccine against HCV. In order to induce an immune response in DBA/2J mice against HCV, we obtained modified mouse mesenchymal stem cel...

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Bibliographic Details
Main Authors: Olga V. Masalova, Ekaterina I. Lesnova, Regina R. Klimova, Ekaterina D. Momotyuk, Vyacheslav V. Kozlov, Alla M. Ivanova, Olga V. Payushina, Nina N. Butorina, Natalia F. Zakirova, Alexander N. Narovlyansky, Alexander V. Pronin, Alexander V. Ivanov, Alla A. Kushch
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Vaccines
Subjects:
hepatitis c virus (hcv)
mesenchymal stem cells (msc)
modified msc
dna immunization
nonstructural hcv proteins
immune response
hcv vaccine
myeloid derived suppressor cells (mdscs)
Online Access:https://www.mdpi.com/2076-393X/8/1/62

Internet

https://www.mdpi.com/2076-393X/8/1/62

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