In vitro-transcribed guide RNAs trigger an innate immune response via the RIG-I pathway.
Clustered, regularly interspaced, short palindromic repeat (CRISPR)-CRISPR-associated 9 (Cas9) genome editing is revolutionizing fundamental research and has great potential for the treatment of many diseases. While editing of immortalized cell lines has become relatively easy, editing of therapeuti...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2018-07-01
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Series: | PLoS Biology |
Online Access: | http://europepmc.org/articles/PMC6049001?pdf=render |