A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization

A Comparative Analysis of the Lipoprotein(a) and Low-Density Lipoprotein Proteomic Profiles Combining Mass Spectrometry and Mendelian Randomization

Background: Lipoprotein(a) (Lp[a]), which consists of a low-density lipoprotein (LDL) bound to apolipoprotein(a), is one of the strongest genetic risk factors for atherosclerotic cardiovascular diseases. Few studies have performed hypothesis-free direct comparisons of the Lp(a) and the LDL proteomes...

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Main Authors: Raphaëlle Bourgeois, MSc, Arnaud Girard, BSc, Nicolas Perrot, MSc, Jakie Guertin, BSc, Patricia L. Mitchell, PhD, Christian Couture, MSc, Clarisse Gotti, MSc, Sylvie Bourassa, PhD, Paolo Poggio, PhD, Elvira Mass, PhD, Romain Capoulade, PhD, Corey A. Scipione, PhD, Audrey-Anne Després, MSc, Patrick Couture, MD, PhD, Arnaud Droit, PhD, Philippe Pibarot, DVM, PhD, Michael B. Boffa, PhD, Sébastien Thériault, MD, MSc, Marlys L. Koschinsky, PhD, Patrick Mathieu, MD, MSc, Benoit J. Arsenault, PhD
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:CJC Open
Online Access:http://www.sciencedirect.com/science/article/pii/S2589790X20302080

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http://www.sciencedirect.com/science/article/pii/S2589790X20302080

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