Improved siRNA/shRNA functionality by mismatched duplex.

Improved siRNA/shRNA functionality by mismatched duplex.

siRNA (small interfering RNA) and shRNA (small hairpin RNA) are powerful and commonly used tools in biomedical research. Currently, siRNAs are generally designed as two 21 nt strands of RNA that include a 19 nt completely complementary part and a 2 nt overhang. However, since the si/shRNAs use the e...

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Bibliographic Details
Main Authors: Haoquan Wu, Hongming Ma, Chunting Ye, Danielle Ramirez, Shuiping Chen, Jessica Montoya, Premlata Shankar, Xiaozhong A Wang, N Manjunath
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3235145?pdf=render

Internet

http://europepmc.org/articles/PMC3235145?pdf=render

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