Effect of Ion Concentration Changes in the Limited Extracellular Spaces on Sarcolemmal Ion Transport and Ca2+ Turnover in a Model of Human Ventricular Cardiomyocyte

Effect of Ion Concentration Changes in the Limited Extracellular Spaces on Sarcolemmal Ion Transport and Ca2+ Turnover in a Model of Human Ventricular Cardiomyocyte

We have developed a computer model of human cardiac ventricular myocyte (CVM), including t-tubular and cleft spaces with the aim of evaluating the impact of accumulation-depletion of ions in restricted extracellular spaces on transmembrane ion transport and ionic homeostasis in human CVM. The model...

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Bibliographic Details
Main Authors: Dana Hrabcová, Michal Pásek, Jiří Šimurda, Georges Christé
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:International Journal of Molecular Sciences
Subjects:
human heart
cardiac cell
t-tubule
intercellular clefts
calcium
ion transport
computer model
Online Access:http://www.mdpi.com/1422-0067/14/12/24271

Internet

http://www.mdpi.com/1422-0067/14/12/24271

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