Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice

Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice

Corneal pain is considered to be a core symptom of ocular surface disruption and inflammation. The management of this debilitating condition is still a therapeutic challenge. Recent evidence supports a role of the opioid system in the management of corneal nociception. However, the functional involv...

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Bibliographic Details
Main Authors: Fanny Joubert, Adrian Guerrero-Moreno, Darine Fakih, Elodie Reboussin, Claire Gaveriaux-Ruff, Maria Carmen Acosta, Juana Gallar, José Alain Sahel, Laurence Bodineau, Christophe Baudouin, William Rostène, Stéphane Mélik-Parsadaniantz, Annabelle Réaux-Le Goazigo
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Corneal pain
Inflammation
Opioid receptor
Electrophysiology
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220309872

Internet

http://www.sciencedirect.com/science/article/pii/S0753332220309872

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