Lysine 268 adjacent to transmembrane helix 5 of hamster P‐glycoprotein is the major photobinding site of iodomycin in CHO B30 cells

Lysine 268 adjacent to transmembrane helix 5 of hamster P‐glycoprotein is the major photobinding site of iodomycin in CHO B30 cells

P‐glycoprotein (Pgp) detoxifies cells by exporting hundreds of chemically dissimilar hydrophobic and amphipathic compounds and is implicated in multidrug resistance (MDR) in the treatment of cancers. Photoaffinity labeling of plasma membrane vesicles of MDR CHO B30 cells with the anthracycline [125I...

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Bibliographic Details
Main Authors: Annette Demmer, Hubert Thole, Manfred Raida, Burkhard Tümmler
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:FEBS Open Bio
Subjects:
ABC transporter
anthracycline
drug‐binding site
Edman sequencing
multidrug resistance
P‐glycoprotein
Online Access:https://doi.org/10.1002/2211-5463.13112

Internet

https://doi.org/10.1002/2211-5463.13112

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