Insulin Influences LPS-Induced TNF-α and IL-6 Release Through Distinct Pathways in Mouse Macrophages from Different Compartments

Background/Aims: Diabetic subjects are more susceptible to infections, which is partially due to insulin deficiency and hyperglycemia. We hypothesized that insulin influences cytokine release by macrophages from diabetic C57BL/6 mice stimulated with lipopolysaccharides (LPS). Methods: Bone marrow-de...

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Bibliographic Details
Main Authors: Fernando H. G. Tessaro, Thais S. Ayala, Eduardo L. Nolasco, Leonardo M. Bella, Joilson O. Martins
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Akt
ERK
Online Access:http://www.karger.com/Article/FullText/479904