Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE

Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE

Leukocyte infiltration is a key step in the development of demyelinating lesions in multiple sclerosis (MS), and molecules mediating leukocyte-endothelial interactions represent prime candidates for the development of therapeutic strategies. Here we studied the effects of blocking the integrin-assoc...

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Bibliographic Details
Main Authors: S. Dijkstra, G. Kooij, R. Verbeek, S.M.A. van der Pol, S. Amor, E.E. Geisert, Jr., C.D. Dijkstra, J.M. van Noort, H.E. de Vries
Format: Article
Language:English
Published: Elsevier 2008-09-01
Series:Neurobiology of Disease
Subjects:
Tetraspanins
CD81
Multiple sclerosis
Transendothelial migration
Therapeutic antibodies
EAE
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108001228

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http://www.sciencedirect.com/science/article/pii/S0969996108001228

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