From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs

From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs

The proteins of the Ly6 family have a three-finger folding as snake venom α-neurotoxins, targeting nicotinic acetylcholine receptors (nAChRs), and some of them, like mammalian secreted Ly6/uPAR protein (SLURP1) and membrane-attached Ly-6/neurotoxin (Lynx1), also interact with distinct nAChR subtypes...

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Bibliographic Details
Main Authors:	Elena V. Kryukova, Natalia S. Egorova, Denis S. Kudryavtsev, Dmitry S. Lebedev, Ekaterina N. Spirova, Maxim N. Zhmak, Aleksandra I. Garifulina, Igor E. Kasheverov, Yuri N. Utkin, Victor I. Tsetlin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-07-01
Series:	Frontiers in Pharmacology
Subjects:	three-finger proteins peptide fragments Ly6 family nicotinic acetylcholine receptors nAChRs
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2019.00748/full

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