From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs

From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs

The proteins of the Ly6 family have a three-finger folding as snake venom α-neurotoxins, targeting nicotinic acetylcholine receptors (nAChRs), and some of them, like mammalian secreted Ly6/uPAR protein (SLURP1) and membrane-attached Ly-6/neurotoxin (Lynx1), also interact with distinct nAChR subtypes...

Full description

Bibliographic Details
Main Authors: Elena V. Kryukova, Natalia S. Egorova, Denis S. Kudryavtsev, Dmitry S. Lebedev, Ekaterina N. Spirova, Maxim N. Zhmak, Aleksandra I. Garifulina, Igor E. Kasheverov, Yuri N. Utkin, Victor I. Tsetlin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
three-finger proteins
peptide fragments
Ly6 family
nicotinic acetylcholine receptors
nAChRs
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00748/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00748/full

Similar Items