Influence of total western diet on docosahexaenoic acid suppression of silica-triggered lupus flaring in NZBWF1 mice.

Lupus is a debilitating multi-organ autoimmune disease clinically typified by periods of flare and remission. Exposing lupus-prone female NZBWF1 mice to crystalline silica (cSiO2), a known human autoimmune trigger, mimics flaring by inducing interferon-related gene (IRG) expression, inflammation, ec...

Full description

Bibliographic Details
Main Authors: Kristen N Gilley, Kathryn A Wierenga, Preeti S Chauhuan, James G Wagner, Ryan P Lewandowski, Elizbeth A Ross, A L Lock, Jack R Harkema, Abby D Benninghoff, James J Pestka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0233183