Genetics of Familial Hypercholesterolemia: New Insights

Genetics of Familial Hypercholesterolemia: New Insights

Familial hypercholesterolemia (FH) is one of the most common monogenic diseases, leading to an increased risk of premature atherosclerosis and its cardiovascular complications due to its effect on plasma cholesterol levels. Variants of three genes (LDL-R, APOB and PCSK9) are the major causes of FH,...

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Bibliographic Details
Main Authors: Michal Vrablik, Lukas Tichý, Tomas Freiberger, Vladimir Blaha, Martin Satny, Jaroslav A. Hubacek
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Genetics
Subjects:
familial hypercholesterolemia
gene score
epidemiology
variants
polygenic FH
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.574474/full

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https://www.frontiersin.org/article/10.3389/fgene.2020.574474/full

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