Novel Thienopyrimidine Derivative, RP-010, Induces β-Catenin Fragmentation and Is Efficacious against Prostate Cancer Cells

Novel Thienopyrimidine Derivative, RP-010, Induces β-Catenin Fragmentation and Is Efficacious against Prostate Cancer Cells

Thienopyrimidines containing a thiophene ring fused to pyrimidine are reported to have a wide-spectrum of anticancer efficacy in vitro. Here, we report for the first time that thieno[3,2-<i>d</i>]pyrimidine-based compounds, also known as the RP series, have efficacy in prostate cancer ce...

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Bibliographic Details
Main Authors: Haneen Amawi, Noor Hussein, Sai H. S. Boddu, Chandrabose Karthikeyan, Frederick E. Williams, Charles R. Ashby, Dayanidhi Raman, Piyush Trivedi, Amit K. Tiwari
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
thienopyrimidines
RP-010
prostate cancer
metastasis
Wnt/β-catenin
apoptosis
Online Access:https://www.mdpi.com/2072-6694/11/5/711

Internet

https://www.mdpi.com/2072-6694/11/5/711

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