A two-hit adversity model in developing rats reveals sex-specific impacts on prefrontal cortex structure and behavior

A two-hit adversity model in developing rats reveals sex-specific impacts on prefrontal cortex structure and behavior

Adversity early in life substantially impacts prefrontal cortex (PFC) development and vulnerability to later-life psychopathology. Importantly, repeated adverse experiences throughout childhood increase the risk for PFC-mediated behavioral deficits more commonly in women. Evidence from animal models...

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Bibliographic Details
Main Authors: Kelsea R. Gildawie, Lilly M. Ryll, Jessica C. Hexter, Shayna Peterzell, Alissa A. Valentine, Heather C. Brenhouse
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Developmental Cognitive Neuroscience
Subjects:
Maternal separation
Prefrontal cortex
Perineuronal nets
Parvalbumin
Sex differences
Anxiety
Online Access:http://www.sciencedirect.com/science/article/pii/S1878929321000153

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http://www.sciencedirect.com/science/article/pii/S1878929321000153

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