Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis

Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis

Abstract Background Multiple sclerosis (MS) is a chronic debilitating immune-mediated disease of the central nervous system (CNS) driven by demyelination and gray matter neurodegeneration. We previously reported an experimental autoimmune encephalomyelitis (EAE) MS mouse model with elevated serum CX...

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Bibliographic Details
Main Authors: Yee Ming Khaw, Claire Cunningham, Abigail Tierney, Mayandi Sivaguru, Makoto Inoue
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
CXCR2
Neutrophil
Neuronal cell death
ROS
Dendritic spine loss
Online Access:https://doi.org/10.1186/s12974-020-1730-y

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