Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis

Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis

Abstract Background Multiple sclerosis (MS) is a chronic debilitating immune-mediated disease of the central nervous system (CNS) driven by demyelination and gray matter neurodegeneration. We previously reported an experimental autoimmune encephalomyelitis (EAE) MS mouse model with elevated serum CX...

Full description

Bibliographic Details
Main Authors: Yee Ming Khaw, Claire Cunningham, Abigail Tierney, Mayandi Sivaguru, Makoto Inoue
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
CXCR2
Neutrophil
Neuronal cell death
ROS
Dendritic spine loss
Online Access:https://doi.org/10.1186/s12974-020-1730-y

Internet

https://doi.org/10.1186/s12974-020-1730-y

Similar Items