Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice

Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice

SUMMARY The site-specific recombinases Cre and Flp can mutate genes in a spatially and temporally restricted manner in mice. Conditional recombination of the tumor suppressor gene p53 using the Cre-loxP system has led to the development of multiple genetically engineered mouse models of human cancer...

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Bibliographic Details
Main Authors: Chang-Lung Lee, Everett J. Moding, Xiaofang Huang, Yifan Li, Loretta Z. Woodlief, Rafaela C. Rodrigues, Yan Ma, David G. Kirsch
Format: Article
Language:English
Published: The Company of Biologists 2012-05-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/5/3/397

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http://dmm.biologists.org/content/5/3/397

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