Association of tamoxifen resistance and lipid reprogramming in breast cancer

Association of tamoxifen resistance and lipid reprogramming in breast cancer

Abstract Background Tamoxifen treatment of estrogen receptor (ER)-positive breast cancer reduces mortality by 31%. However, over half of advanced ER-positive breast cancers are intrinsically resistant to tamoxifen and about 40% will acquire the resistance during the treatment. Methods In order to ex...

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Bibliographic Details
Main Authors: Susanne Hultsch, Matti Kankainen, Lassi Paavolainen, Ruusu-Maaria Kovanen, Elina Ikonen, Sara Kangaspeska, Vilja Pietiäinen, Olli Kallioniemi
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Cancer
Subjects:
Tamoxifen resistance
Breast cancer
Lysosomal membrane permeabilization
RNA-sequencing
Drug sensitivity and resistance testing
Online Access:http://link.springer.com/article/10.1186/s12885-018-4757-z

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http://link.springer.com/article/10.1186/s12885-018-4757-z

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