Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer’s Disease

Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer’s Disease

Acetylcholinesterase (AChE) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. Deficits in cholinergic neurotransmitters are linked closely with the progression of Alzheimer’s disease (AD), which is a neurodegenerative disorder characteri...

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Bibliographic Details
Main Authors: Minky Son, Chanin Park, Shailima Rampogu, Amir Zeb, Keun Woo Lee
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
acetylcholinesterase
Alzheimer’s disease
molecular docking
molecular dynamics simulation
pharmacophore modeling
Online Access:https://www.mdpi.com/1422-0067/20/4/1000

Internet

https://www.mdpi.com/1422-0067/20/4/1000

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