CP-25 combined with MTX/ LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation

Objective: CP-25 attenuates arthritis progression in animal models by inhibiting G protein-coupled receptor kinase 2 (GRK2) membrane expression. This study compared groups treated with high-dose methotrexate (MTX)/leflunomide (LEF) and CP-25 combined with low-dose MTX/LEF in an adjuvant-induced arth...

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Bibliographic Details
Main Authors: Xuezhi Yang, Yingjie Zhao, Xiaoyi Jia, Chun Wang, Yujing Wu, Lingling Zhang, Yan Chang, Wei Wei
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
MTX
LEF
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218377527