CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression
Alterations in intrinsic plasticity are important in epilepsy. Here the authors show that the epigenetic factor CDYL regulates the gene expression of the voltage gated sodium channel, Nav1.6, which contributes to seizures in a rat model of epilepsy.
Bibliographic Details
| Main Authors: |
Yongqing Liu,
Shirong Lai,
Weining Ma,
Wei Ke,
Chan Zhang,
Shumeng Liu,
Yu Zhang,
Fei Pei,
Shaoyi Li,
Ming Yi,
Yousheng Shu,
Yongfeng Shang,
Jing Liang,
Zhuo Huang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-00368-z
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