CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression

CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression

Alterations in intrinsic plasticity are important in epilepsy. Here the authors show that the epigenetic factor CDYL regulates the gene expression of the voltage gated sodium channel, Nav1.6, which contributes to seizures in a rat model of epilepsy.

Bibliographic Details
Main Authors: Yongqing Liu, Shirong Lai, Weining Ma, Wei Ke, Chan Zhang, Shumeng Liu, Yu Zhang, Fei Pei, Shaoyi Li, Ming Yi, Yousheng Shu, Yongfeng Shang, Jing Liang, Zhuo Huang
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00368-z

Internet

https://doi.org/10.1038/s41467-017-00368-z

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