Predicting antigen specificity of single T cells based on TCR CDR3 regions

Abstract It has recently become possible to simultaneously assay T‐cell specificity with respect to large sets of antigens and the T‐cell receptor sequence in high‐throughput single‐cell experiments. Leveraging this new type of data, we propose and benchmark a collection of deep learning architectur...

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Bibliographic Details
Main Authors: David S Fischer, Yihan Wu, Benjamin Schubert, Fabian J Theis
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:Molecular Systems Biology
Subjects:
Online Access:https://doi.org/10.15252/msb.20199416