Decreased Netrin-1 and Correlated Th17/Tregs Balance Disorder in Aβ1–42 Induced Alzheimer’s Disease Model Rats

Decreased Netrin-1 and Correlated Th17/Tregs Balance Disorder in Aβ1–42 Induced Alzheimer’s Disease Model Rats

There is increasing evidence indicating that inflammation represents a key pathological component of Alzheimer’s disease (AD). A possible factor that may contribute to this process is netrin-1, a neuronal guidance molecule. This molecule has been shown to exert an unexpected immunomodulatory functio...

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Bibliographic Details
Main Authors: Lina Sun, Ting Ju, Tianhang Wang, Liang Zhang, Feifan Ding, Yan Zhang, Ran An, Yilei Sun, You Li, Yidan Lu, Xin Zhang, Lijun Chi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
inflammation
netrin-1
Th17
Tregs
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00124/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00124/full

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