Analgesic drug development: proof-of-mechanism and proof-of-concept in early phase clinical studies

Effective treatment for many pain disorders is still lacking, which is due to the complexity of pain in general and of the underlying pathology of many pain syndromes in particular. This results in the majority of investigational analgesic drugs failing to reach registration, either due to lack of e...

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Bibliographic Details
Main Authors: Hemme J. Hijma, MSc, Geert Jan Groeneveld, MD, PhD
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Medicine in Drug Discovery
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S259009862100004X