Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis

LUBAC is a ubiquitin ligase complex of HOIL-1, HOIP and SHARPIN important for signal transduction of a range of stimuli. Here the authors define the function of all three LUBAC components in T cell development and homeostasis.

Bibliographic Details
Main Authors: Charis E. Teh, Najoua Lalaoui, Reema Jain, Antonia N. Policheni, Melanie Heinlein, Silvia Alvarez-Diaz, Julie M. Sheridan, Eva Rieser, Stefanie Deuser, Maurice Darding, Hui-Fern Koay, Yifang Hu, Fiona Kupresanin, Lorraine A. O’Reilly, Dale I. Godfrey, Gordon K. Smyth, Philippe Bouillet, Andreas Strasser, Henning Walczak, John Silke, Daniel H. D. Gray
Format: Article
Language:English
Published: Nature Publishing Group 2016-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13353

Internet

https://doi.org/10.1038/ncomms13353

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