Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy
Integration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here, the authors generate single-drug nanoparticles by hybridising lysomotropic detergents and the bisaminoquinoline-based autophagy inhibitor, and show thei...
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| Language: | English |
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Nature Publishing Group
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18399-4 |
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doaj-c1bb3fa64a58463a9a7b7509b2e89b612021-09-19T11:50:33ZengNature Publishing GroupNature Communications2041-17232020-09-0111111210.1038/s41467-020-18399-4Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapyZhao Ma0Jin Li1Kai Lin2Mythili Ramachandran3Dalin Zhang4Megan Showalter5Cristabelle De Souza6Aaron Lindstrom7Lucas N. Solano8Bei Jia9Shiro Urayama10Yuyou Duan11Oliver Fiehn12Tzu-yin Lin13Minyong Li14Yuanpei Li15Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California DavisDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California DavisDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California DavisDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California DavisDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California DavisWest Coast Metabolomics Center, University of California DavisDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California DavisDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California DavisDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California DavisDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California DavisDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of California DavisInstitutes for Life Sciences, School of Medicine, South China University of TechnologyWest Coast Metabolomics Center, University of California DavisDivision of Hematology and Oncology, Department of Internal Medicine, University of California DavisDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong UniversityDepartment of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California DavisIntegration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here, the authors generate single-drug nanoparticles by hybridising lysomotropic detergents and the bisaminoquinoline-based autophagy inhibitor, and show their therapeutic potential as autophagy-inhibition based combination therapy.https://doi.org/10.1038/s41467-020-18399-4 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Zhao Ma Jin Li Kai Lin Mythili Ramachandran Dalin Zhang Megan Showalter Cristabelle De Souza Aaron Lindstrom Lucas N. Solano Bei Jia Shiro Urayama Yuyou Duan Oliver Fiehn Tzu-yin Lin Minyong Li Yuanpei Li |
| spellingShingle |
Zhao Ma Jin Li Kai Lin Mythili Ramachandran Dalin Zhang Megan Showalter Cristabelle De Souza Aaron Lindstrom Lucas N. Solano Bei Jia Shiro Urayama Yuyou Duan Oliver Fiehn Tzu-yin Lin Minyong Li Yuanpei Li Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy Nature Communications |
| author_facet |
Zhao Ma Jin Li Kai Lin Mythili Ramachandran Dalin Zhang Megan Showalter Cristabelle De Souza Aaron Lindstrom Lucas N. Solano Bei Jia Shiro Urayama Yuyou Duan Oliver Fiehn Tzu-yin Lin Minyong Li Yuanpei Li |
| author_sort |
Zhao Ma |
| title |
Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy |
| title_short |
Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy |
| title_full |
Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy |
| title_fullStr |
Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy |
| title_full_unstemmed |
Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy |
| title_sort |
pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-09-01 |
| description |
Integration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here, the authors generate single-drug nanoparticles by hybridising lysomotropic detergents and the bisaminoquinoline-based autophagy inhibitor, and show their therapeutic potential as autophagy-inhibition based combination therapy. |
| url |
https://doi.org/10.1038/s41467-020-18399-4 |
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