Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy

Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy

Integration of the unique advantages of the fields of drug discovery and drug delivery is invaluable for the advancement of drug development. Here, the authors generate single-drug nanoparticles by hybridising lysomotropic detergents and the bisaminoquinoline-based autophagy inhibitor, and show thei...

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Bibliographic Details
Main Authors: Zhao Ma, Jin Li, Kai Lin, Mythili Ramachandran, Dalin Zhang, Megan Showalter, Cristabelle De Souza, Aaron Lindstrom, Lucas N. Solano, Bei Jia, Shiro Urayama, Yuyou Duan, Oliver Fiehn, Tzu-yin Lin, Minyong Li, Yuanpei Li
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18399-4

Internet

https://doi.org/10.1038/s41467-020-18399-4

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