Preparation of 2-heteroatom substituted 4-oxo-4-arylbutanoates via thio- and aza-Michael addition

Preparation of 2-heteroatom substituted 4-oxo-4-arylbutanoates via thio- and aza-Michael addition

Efficient regioselective conjugate additions of thiophenols and benzotriazole to 4-aryl-4-oxobut-2-enoates have been achieved under mild conditions. Thus a variety of 2-arylthio-4-oxo-4-arylbutanoates and 2- benzotriazolyl-4-oxo-4-arylbutanoates were conveniently synthesized in good to excellent...

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Bibliographic Details
Main Authors: Liu Huili, Lv Xin, Zhou Liejin, Yin Ruifeng, Wang Xiaoxia
Format: Article
Language:English
Published: Serbian Chemical Society 2012-01-01
Series:Journal of the Serbian Chemical Society
Subjects:
Michael addition
thiophenol
benzotriazole
4-aryl-4-oxobut-2-enoate
Online Access:http://www.doiserbia.nb.rs/img/doi/0352-5139/2012/0352-51391100202L.pdf
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spelling doaj-c1b4a59b689f48539a2d497e70a2cdbf2020-11-24T22:59:11ZengSerbian Chemical Society Journal of the Serbian Chemical Society0352-51392012-01-0177558158810.2298/JSC110526202LPreparation of 2-heteroatom substituted 4-oxo-4-arylbutanoates via thio- and aza-Michael additionLiu HuiliLv XinZhou LiejinYin RuifengWang XiaoxiaEfficient regioselective conjugate additions of thiophenols and benzotriazole to 4-aryl-4-oxobut-2-enoates have been achieved under mild conditions. Thus a variety of 2-arylthio-4-oxo-4-arylbutanoates and 2- benzotriazolyl-4-oxo-4-arylbutanoates were conveniently synthesized in good to excellent yields.http://www.doiserbia.nb.rs/img/doi/0352-5139/2012/0352-51391100202L.pdfMichael additionthiophenolbenzotriazole4-aryl-4-oxobut-2-enoate
collection DOAJ
language English
format Article
sources DOAJ
author Liu Huili
Lv Xin
Zhou Liejin
Yin Ruifeng
Wang Xiaoxia
spellingShingle Liu Huili
Lv Xin
Zhou Liejin
Yin Ruifeng
Wang Xiaoxia
Preparation of 2-heteroatom substituted 4-oxo-4-arylbutanoates via thio- and aza-Michael addition
Journal of the Serbian Chemical Society
Michael addition
thiophenol
benzotriazole
4-aryl-4-oxobut-2-enoate
author_facet Liu Huili
Lv Xin
Zhou Liejin
Yin Ruifeng
Wang Xiaoxia
author_sort Liu Huili
title Preparation of 2-heteroatom substituted 4-oxo-4-arylbutanoates via thio- and aza-Michael addition
title_short Preparation of 2-heteroatom substituted 4-oxo-4-arylbutanoates via thio- and aza-Michael addition
title_full Preparation of 2-heteroatom substituted 4-oxo-4-arylbutanoates via thio- and aza-Michael addition
title_fullStr Preparation of 2-heteroatom substituted 4-oxo-4-arylbutanoates via thio- and aza-Michael addition
title_full_unstemmed Preparation of 2-heteroatom substituted 4-oxo-4-arylbutanoates via thio- and aza-Michael addition
title_sort preparation of 2-heteroatom substituted 4-oxo-4-arylbutanoates via thio- and aza-michael addition
publisher Serbian Chemical Society
series Journal of the Serbian Chemical Society
issn 0352-5139
publishDate 2012-01-01
description Efficient regioselective conjugate additions of thiophenols and benzotriazole to 4-aryl-4-oxobut-2-enoates have been achieved under mild conditions. Thus a variety of 2-arylthio-4-oxo-4-arylbutanoates and 2- benzotriazolyl-4-oxo-4-arylbutanoates were conveniently synthesized in good to excellent yields.
topic Michael addition
thiophenol
benzotriazole
4-aryl-4-oxobut-2-enoate
url http://www.doiserbia.nb.rs/img/doi/0352-5139/2012/0352-51391100202L.pdf
work_keys_str_mv AT liuhuili preparationof2heteroatomsubstituted4oxo4arylbutanoatesviathioandazamichaeladdition
AT lvxin preparationof2heteroatomsubstituted4oxo4arylbutanoatesviathioandazamichaeladdition
AT zhouliejin preparationof2heteroatomsubstituted4oxo4arylbutanoatesviathioandazamichaeladdition
AT yinruifeng preparationof2heteroatomsubstituted4oxo4arylbutanoatesviathioandazamichaeladdition
AT wangxiaoxia preparationof2heteroatomsubstituted4oxo4arylbutanoatesviathioandazamichaeladdition
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