A Novel ALDH2 Activator AD-9308 Improves Diastolic and Systolic Myocardial Functions in Streptozotocin-Induced Diabetic Mice

A Novel ALDH2 Activator AD-9308 Improves Diastolic and Systolic Myocardial Functions in Streptozotocin-Induced Diabetic Mice

Diabetes mellitus has reached epidemic proportion worldwide. One of the diabetic complications is cardiomyopathy, characterized by early left ventricular (LV) diastolic dysfunction, followed by development of systolic dysfunction and ventricular dilation at a late stage. The pathogenesis is multifac...

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Bibliographic Details
Main Authors: Hsiao-Lin Lee, Siow-Wey Hee, Chin-Feng Hsuan, Wenjin Yang, Jing-Yong Huang, Ya-Ling Lin, Chih-Neng Hsu, Juey-Jen Hwang, Shiau-Mei Chen, Zhi-Zhong Ding, Tung-Yuan Lee, Yu-Chiao Lin, Feng-Chiao Tsai, Wei-Lun Su, Li-Yun Chueh, Meng-Lun Hsieh, Che-Hong Chen, Daria Mochly-Rosen, Yi-Cheng Chang, Lee-Ming Chuang
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antioxidants
Subjects:
diabetic cardiomyopathy
4-hydroxy-2-nonenal
mitochondrial aldehyde dehydrogenase 2
AD-9308
Online Access:https://www.mdpi.com/2076-3921/10/3/450

Internet

https://www.mdpi.com/2076-3921/10/3/450

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