Recombinant hTRBP and hPACT Modulate hAgo2-Catalyzed siRNA-Mediated Target RNA Cleavage In Vitro.

Recombinant hTRBP and hPACT Modulate hAgo2-Catalyzed siRNA-Mediated Target RNA Cleavage In Vitro.

The human TAR RNA-binding protein (hTRBP) and protein activator of protein kinase R (hPACT) are important players in RNA interference (RNAi). Together with hArgonaute2 (hAgo2) and hDicer they have been reported to form the RISC-loading complex (RLC). Among other functions, hTRBP was suggested to ass...

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Bibliographic Details
Main Authors: Sarah Willkomm, Andrea Deerberg, Johannes Heidemann, Friedemann Flügge, Janica Meine, Rui Hu, Rosel Kretschmer-Kazemi Far, Tobias Restle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4718636?pdf=render

Internet

http://europepmc.org/articles/PMC4718636?pdf=render

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