Long-term follow-up of patients with anti-cyclic citrullinated peptide antibody-positive connective tissue disease: a retrospective observational study including information on the HLA-DRB1 allele and citrullination dependency

Long-term follow-up of patients with anti-cyclic citrullinated peptide antibody-positive connective tissue disease: a retrospective observational study including information on the HLA-DRB1 allele and citrullination dependency

Abstract Background The anti-cyclic citrullinated peptide (CCP) antibody is a diagnostic biomarker of rheumatoid arthritis (RA). However, some non-RA connective tissue disease (CTD) patients also test positive for the anti-CCP antibody and, thus, may ultimately develop RA. We retrospectively investi...

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Bibliographic Details
Main Authors: Takeshi Iwasaki, Shuichiro Nakabo, Chikashi Terao, Kosaku Murakami, Ran Nakashima, Motomu Hashimoto, Yoshitaka Imura, Naoichiro Yukawa, Hajime Yoshifuji, Yasuo Miura, Kimiko Yurugi, Taira Maekawa, Myrthe A. M. van Delft, Leendert A. Trouw, Takao Fujii, Tsuneyo Mimori, Koichiro Ohmura
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Arthritis Research & Therapy
Subjects:
Anti-cyclic citrullinated peptide antibody
Connective tissue disease
Rheumatoid arthritis
Shared epitope
Online Access:http://link.springer.com/article/10.1186/s13075-020-02351-4

Internet

http://link.springer.com/article/10.1186/s13075-020-02351-4

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