A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin

A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin

Abstract Background Severe hypercholesterolemia (HC, LDL‐C > 4.9 mmol/L) affects over 30 million people worldwide. In this study, we validated a new polygenic risk score (PRS) for LDL‐C. Methods Summary statistics from the Global Lipid Genome Consortium and genotype data from two large population...

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Bibliographic Details
Main Authors: Luis G. Leal, Clive Hoggart, Marjo‐Riitta Jarvelin, Karl‐Heinz Herzig, Michael J. E. Sternberg, Alessia David
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
hypercholesterolemia
lipids
polygenic risk score
risk stratification
Online Access:https://doi.org/10.1002/mgg3.1248

Internet

https://doi.org/10.1002/mgg3.1248

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