Inhibition of the Prefrontal Projection to the Nucleus Accumbens Enhances Pain Sensitivity and Affect

Inhibition of the Prefrontal Projection to the Nucleus Accumbens Enhances Pain Sensitivity and Affect

Cortical mechanisms that regulate acute or chronic pain remain poorly understood. The prefrontal cortex (PFC) exerts crucial control of sensory and affective behaviors. Recent studies show that activation of the projections from the PFC to the nucleus accumbens (NAc), an important pathway in the bra...

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Bibliographic Details
Main Authors: Haocheng Zhou, Erik Martinez, Harvey H. Lin, Runtao Yang, Jahrane Antonio Dale, Kevin Liu, Dong Huang, Jing Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
corticostriatal circuits
prefrontal cortex (PFC)
prelimbic cortex
nucleus accumbens (NAc)
acute pain
chronic pain
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00240/full

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https://www.frontiersin.org/article/10.3389/fncel.2018.00240/full

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