Cartilage constructs engineered from chondrocytes overexpressing IGF-I improve the repair of osteochondral defects in a rabbit model

Cartilage constructs engineered from chondrocytes overexpressing IGF-I improve the repair of osteochondral defects in a rabbit model

Tissue engineering combined with gene therapy is a promising approach for promoting articular cartilage repair. Here, we tested the hypothesis that engineered cartilage with chondrocytes overexpressing a human insulin-like growth factor I (IGF-I) gene can enhance the repair of osteochondral defects,...

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Bibliographic Details
Main Authors: H Madry, G Kaul, D Zurakowski, G Vunjak-Novakovic, M Cucchiarini
Format: Article
Language:English
Published: AO Research Institute Davos 2013-04-01
Series:European Cells & Materials
Subjects:
Tissue engineering
gene therapy
articular chondrocytes
bioreactor
insulin-like growth factor I
transplantation
scaffold
osteochondral defects
cartilage repair
osteoarthritis
Online Access:http://www.ecmjournal.org/journal/papers/vol025/pdf/v025a17.pdf

Internet

http://www.ecmjournal.org/journal/papers/vol025/pdf/v025a17.pdf

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