Rescuing loading induced bone formation at senescence.

The increasing incidence of osteoporosis worldwide requires anabolic treatments that are safe, effective, and, critically, inexpensive given the prevailing overburdened health care systems. While vigorous skeletal loading is anabolic and holds promise, deficits in mechanotransduction accrued with ag...

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Bibliographic Details
Main Authors: Sundar Srinivasan, Brandon J Ausk, Jitendra Prasad, Dewayne Threet, Steven D Bain, Thomas S Richardson, Ted S Gross
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2936512?pdf=render