Nitric Oxide Is a Mediator of Antiproliferative Effects Induced by Proinflammatory Cytokines on Pancreatic Beta Cells

Nitric oxide (NO) is involved in several biological processes. In type 1 diabetes mellitus (T1DM), proinflammatory cytokines activate an inducible isoform of NOS (iNOS) in β cells, thus increasing NO levels and inducing apoptosis. The aim of the current study is to determine the role of NO (1) in th...

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Bibliographic Details
Main Authors: Laura Quintana-Lopez, Manuel Blandino-Rosano, Gonzalo Perez-Arana, Alberto Cebada-Aleu, Alfonso Lechuga-Sancho, Manuel Aguilar-Diosdado, Carmen Segundo
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2013/905175