Disequilibrium of BMP2 Levels in the Breast Stem Cell Niche Launches Epithelial Transformation by Overamplifying BMPR1B Cell Response

Disequilibrium of BMP2 Levels in the Breast Stem Cell Niche Launches Epithelial Transformation by Overamplifying BMPR1B Cell Response

Understanding the mechanisms of cancer initiation will help to prevent and manage the disease. At present, the role of the breast microenvironment in transformation remains unknown. As BMP2 and BMP4 are important regulators of stem cells and their niches in many tissues, we investigated their functi...

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Bibliographic Details
Main Authors: Marion Chapellier, Elodie Bachelard-Cascales, Xenia Schmidt, Flora Clément, Isabelle Treilleux, Emmanuel Delay, Alexandre Jammot, Christine Ménétrier-Caux, Gaëtan Pochon, Roger Besançon, Thibault Voeltzel, Claude Caron de Fromentel, Christophe Caux, Jean-Yves Blay, Richard Iggo, Véronique Maguer-Satta
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114003841

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http://www.sciencedirect.com/science/article/pii/S2213671114003841

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