Evaluation of antitumor potential of synthesized novel 2-substituted 4-anilinoquinazolines as quinazoline-pyrrole hybrids in MCF-7 human breast cancer cell line and A-549 human lung adenocarcinoma cell lines

Evaluation of antitumor potential of synthesized novel 2-substituted 4-anilinoquinazolines as quinazoline-pyrrole hybrids in MCF-7 human breast cancer cell line and A-549 human lung adenocarcinoma cell lines

Abstract Background A series of novel 2 substituted 4-anilinoquinazolines-pyrrole hybrids were synthesized, and cytotoxic activity were evaluated using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. Methods The cell line used for the activity was MCF-7 breast cancer cell...

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Bibliographic Details
Main Authors: Raju Bathula, Presenjit Mondal, Ramakrishna Raparla, Shobha Rani Satla
Format: Article
Language:English
Published: SpringerOpen 2020-07-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Quinazolines
Pyrrole
Cytotoxic
Breast cancer
Adenocarcinoma
Online Access:http://link.springer.com/article/10.1186/s43094-020-00059-5

Internet

http://link.springer.com/article/10.1186/s43094-020-00059-5

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