Effects of pacing site and stimulation history on alternans dynamics and the development of complex spatiotemporal patterns in cardiac tissue

Alternans of action potential duration has been associated with T-wave alternans and the development of arrhythmias because it produces large gradients of repolarization. However, little is known about alternans dynamics in large mammalian hearts. Using optical mapping to record electrical activatio...

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Bibliographic Details
Main Authors: Alessio eGizzi, Elizabeth eCherry, Robert F Gilmour, Stefan eLuther, Simonetta eFilippi, Flavio H Fenton
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00071/full