Epigenetic Regulation of Wnt Signaling by Carboxamide-Substituted Benzhydryl Amines that Function as Histone Demethylase Inhibitors

Epigenetic Regulation of Wnt Signaling by Carboxamide-Substituted Benzhydryl Amines that Function as Histone Demethylase Inhibitors

Summary: Aberrant activation of Wnt signaling triggered by mutations in either Adenomatous Polyposis Coli (APC) or CTNNB1 (β-catenin) is a hallmark of colorectal cancers (CRC). As part of a program to develop epigenetic regulators for cancer therapy, we developed carboxamide-substituted benzhydryl a...

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Bibliographic Details
Main Authors: Wen Zhang, Vitaliy M. Sviripa, Yanqi Xie, Tianxin Yu, Meghan G. Haney, Jessica S. Blackburn, Charles A. Adeniran, Chang-Guo Zhan, David S. Watt, Chunming Liu
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:iScience
Subjects:
Biological Sciences
Biochemistry
Biochemical Mechanism
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220309925

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http://www.sciencedirect.com/science/article/pii/S2589004220309925

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